Melanotan II (i) is a synthetic analogue of the naturally-occurring melanocortin peptide hormone α-melanocyte-stimulating hormone (α-MSH) that in usage has been shown to produce melanogenesis (part of the tanning process that produces darkening pigmentation in the skin) and have aphrodisiac effects in preliminary studies and clinical trials. Developed at the University of Arizona, it is a cyclic lactam analogue of α-MSH with the amino acid sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2.
As of 2016, no product containing melanotan II has ever received approval for use from any governmental drug regulatory bodies outside of sanctioned animal and human clinical trials. Unlicensed and untested powders sold as "melanotan II" are found on the Internet and are reported to be used by thousands of members of the general public for sunless tanning. Multiple regulatory bodies have warned consumers the peptides may be unsafe and ineffective in usage with one regulatory agency warning that consumers who purchase any product labeled "melanotan" risk buying a counterfeit drug. Medical researchers and Clinuvel Pharmaceuticals, the company developing the related peptide afamelanotide (also known as melanotan I), have warned consumers that counterfeit products sold using the names "melanotan I and II", "pose a hazard to public health".
Chinese alias: Melanotan acetate II MELANOTAN II ACETATE; Melanotan acetate II MELANOTANII ACETATE (MT-2); Melanotan acetate II; Melanotan acetate II; Ac - [Nle4Asp5D-Phe7Lys10] alpha-MSH - (4-10) - NH2;
English Name: Melanotan II acetate salt
English alias: (3S, 6S, 9R, 12S, 15S, 23S) - 15 - [(2S) - 2-acetamidohexanoyl] amino] - 9-benzyl-6 - [3 - (diaminomethylideneamino) propyl] - 12 - (1H-imidazol-5-ylmethyl) - 3 - (1H-indol-3-ylmethyl) - 2, 5, 8, 11, 14, 17-hexaoxo-1, 4, 7, 10, 13, 18-cyclo-xanoxanoxane
Molecular formula: C50H69N15O9
Molecular weight: 1024.18000
Precise quality: 1023.54000
Appearance and properties: solid
Density: 1.43 g/cm3
Refractive index: 1.669
Storage conditions: -20 C